Fig. 8. Cd acts through ROS and p38 to upregulate COX-2. (A), (B), (C) and (D): HT-29 cells were treated with Cd (100 nM) for 24 hours in the presence or absence of NAC and/or SB202190. COX-2 protein levels were assessed by western blotting. (E): Cells were pre-treated with SB202190 for 30 minutes followed by Cd (100 nM) for 12 hours. COX-2 transcription was evaluated using the COX-2 promoter-driven luciferase reporter activity. Values are represented as mean ± SEM of n=3. * denotes p<0.05, ** denotes p<0.01.